Selected Publications

At the end of this page, you can find the full list of publications. All papers are also available on PubMed.

BCG vaccination-induced emergency granulopoiesis provides rapid protection from neonatal sepsis

BCG reduces risk for all-cause mortality among newborns by 50%! But the mechanisms were unknown. So we went to work sorting it out. It’s the neutrophils.

Byron Brook, Danny Harbeson, Casey Shannon, Bing Cai…Tobias R. Kollmann & Nelly Amenyogbe

Brook B. et al. Sci Trans Med 2020

See this New Scientist article by Layal Liverpool.

Angiogenesis-associated pathways play critical roles in neonatal sepsis outcomes

Why are some neonatal sepsis outcomes better than others? Seems like angiogenesis is a big part of the story.

Mario Fidanza, Julie Hibbert, Erica Acton, Danny Harbeson…Tobias Kollmann, Nelly Amenyogbe & Amy H. Lee

Fidanza et al. Scientific Reports 2024

Dynamic molecular changes during the first week of human life follow a robust developmental trajectory

Newborns might not look like they’re doing much, there there are massive immune developments happening under the hood. Here we find that these developments are remarkably similar across diverse populations.

Amy H. Lee, Casey P. Shannon, Nelly Amenyogbe, Tue B. Bennike, Joann Diray-Arce, Olubykola T. Idoko…Peter C. Richmond, Rebecca Ford, The EPIC Consortium & Tobias R. Kollmann

Lee et al. Nat Comm 2019.

See this CBC news article by Marcy Cutter.

Biogeography of the Relationship between the Child Gut Microbiome and Innate Immune System

From roughly 2006, as the microbiome field took off, we gained awareness of its’ profound impact on our immune health. In this paper we explored correlations between the microbiome and systemic immune function in children around the world.

Nelly Amenyogbe, Pedro Dimitriu, Kinga K. Smolen, Eric M. Brown, Casey P. Shannon…William W. Mohn

Amenyogbe et al. mBio 2019.

Energy Demands of Early Life Drive a Disease Tolerant Phenotype and Dictate Outcome in Neonatal Bacterial Sepsis

Newborns have long been described as immunologically “immature”. We disagree. In this review, we propose that newborn immunity is well-adapted to the metabolic demands of this life stage. Finding ways to improve newborn health means we need to keep this at the forefront.

Danny Haerbeson, Freddy Francis, Winnie Bao, Nelly Amenyogbe, Tobias R. Kollmann

Harbeson et al. Front Immunol 2018.